ERBIL, Kurdistan Region of Iraq - At least two US army soldiers and a civilian interpreter were killed and three were wounded during an Islamic State (ISIS) attack on the US-led global coalition and Syrian security forces in Syria’s western province of Homs, US Central Command (CENTCOM) revealed on Saturday.

“Two [US] service members and one [US] civilian were killed, and three service members were injured, as a result of an ambush by a lone ISIS gunman in Syria,” read a CENTCOM statement, adding that the perpetrator was killed.

“As a matter of respect for the families and in accordance with Department of War policy, the identities of the service members will be withheld until 24 hours after their next of kin have been notified,” the statement added.

The attack took place near the city of Palmyra in the province of Homs during a joint field patrol. In addition to the American casualties, one Syrian security personnel was killed and several others were injured, state media reported.

The field tour marks the first by the US-led coalition in the Syrian desert, a high-risk area outside the control of the Syrian government, a Pentagon official told The New Region.

The gunman was killed during the altercations.

“Let it be known, if you target Americans — anywhere in the world — you will spend the rest of your brief, anxious life knowing the United States will hunt you, find you, and ruthlessly kill you,” wrote US Secretary of Defense Pete Hegseth on X following the attack.

US Envoy to Syria Tom Barrack condemned the attack, while reiterating commitment to “defeating terrorism with our Syrian partners.”

Mazloum Abdi, commander of the Kurdish-led Syrian Democratic Forces (SDF), expressed “regret” for the incident, and wished a speedy recovery for the wounded.

“The increase in these attacks necessitates greater resolve and concerted national efforts in combating terrorism and its cells,” wrote Abdi.

The SDF extended condolences to the US army and the American people over the incident, vowing a "decisive" response.

"As we strongly condemn this terrorist attack, we affirm that our forces, in full partnership with our allies in the International Coalition, will not allow terrorist organizations to reorganize their ranks or to threaten the security of the region and the world once again. The response will be decisive and direct against those responsible for the attack and those who support them," read a statement from the SDF.

Syrian interior ministry spokesperson Noureddine al-Baba told state media that the security forces had “issued prior warnings” to the US forces regarding a potential ISIS attack, noting that “The international coalition forces did not take the Syrian warnings… into account.”

Syria joined the international coalition in November, becoming the body’s 90th partner to join the global fight against ISIS.

The announcement was made a day after Syrian President Ahmad al-Sharaa visited the US and met with US President Donald Trump, during which Washington temporarily suspended key Caesar Act sanctions on Damascus and suggested that Syria should join the coalition.

Before its rise to power, the Sharaa-led Hay’at Tahrir al-Sham (HTS) faction fought alongside many local and international jihadist entities in the fight against Bashar al-Assad’s regime.

Syrian authorities now seek to bolster their relations with the West in order to normalize diplomatic relations, boost the economy, and support the country’s reconstruction, which involves joining the Western states in fighting the Islamic militant group.